Positron emission tomography shows that impaired frontal lobe functioning in Parkinson’s disease is related to dopaminergic hypofunction in the caudate nucleus
Identifieur interne : 001A31 ( Main/Exploration ); précédent : 001A30; suivant : 001A32Positron emission tomography shows that impaired frontal lobe functioning in Parkinson’s disease is related to dopaminergic hypofunction in the caudate nucleus
Auteurs : Anna Brück [Finlande] ; Raija Portin [Finlande] ; Arja Lindell [Finlande] ; Arto Laihinen [Finlande] ; Jörgen Bergman [Finlande] ; Merja Haaparanta [Finlande] ; Olof Solin [Finlande] ; Juha O. Rinne [Finlande]Source :
- Neuroscience Letters [ 0304-3940 ] ; 2001.
English descriptors
- KwdEn :
Abstract
We examined the relation between the dopaminergic function and the cognitive performance of patients with Parkinson's disease (PD). The subject sample consisted of ten patients in the early course of PD and with no previous antiparkinsonian medication. The dopaminergic function of the caudate nucleus and the putamen was studied with [18F]fluorodopa positron emission tomography, and the cognitive performance with a comprehensive battery of neuropsychological tests including tests sensitive to frontal lobe function. The decreased [18F]fluorodopa uptake in the right caudate nucleus was found to be related to slow processing time, measured as the difference between the incongruent and the congruent subtests of the Stroop Test (r=−0.85, P=0.002), a similar trend was seen in the left caudate (r=−0.60, P=0.07). Similar correlation was not detected in the putamen. The present findings provide evidence that the decreased dopaminergic function in the right caudate nucleus is related to the impaired performance in tests sensitive to frontal lobe function in patients at an early stage of PD and with no antiparkinsonian medication.
Url:
DOI: 10.1016/S0304-3940(01)02124-3
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Positron emission tomography shows that impaired frontal lobe functioning in Parkinson’s disease is related to dopaminergic hypofunction in the caudate nucleus</title>
<author><name sortKey="Bruck, Anna" sort="Bruck, Anna" uniqKey="Bruck A" first="Anna" last="Brück">Anna Brück</name>
</author>
<author><name sortKey="Portin, Raija" sort="Portin, Raija" uniqKey="Portin R" first="Raija" last="Portin">Raija Portin</name>
</author>
<author><name sortKey="Lindell, Arja" sort="Lindell, Arja" uniqKey="Lindell A" first="Arja" last="Lindell">Arja Lindell</name>
</author>
<author><name sortKey="Laihinen, Arto" sort="Laihinen, Arto" uniqKey="Laihinen A" first="Arto" last="Laihinen">Arto Laihinen</name>
</author>
<author><name sortKey="Bergman, Jorgen" sort="Bergman, Jorgen" uniqKey="Bergman J" first="Jörgen" last="Bergman">Jörgen Bergman</name>
</author>
<author><name sortKey="Haaparanta, Merja" sort="Haaparanta, Merja" uniqKey="Haaparanta M" first="Merja" last="Haaparanta">Merja Haaparanta</name>
</author>
<author><name sortKey="Solin, Olof" sort="Solin, Olof" uniqKey="Solin O" first="Olof" last="Solin">Olof Solin</name>
</author>
<author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:C422F2766080D75DEFC7CD0B588A2EEE9E9832F8</idno>
<date when="2001" year="2001">2001</date>
<idno type="doi">10.1016/S0304-3940(01)02124-3</idno>
<idno type="url">https://api.istex.fr/document/C422F2766080D75DEFC7CD0B588A2EEE9E9832F8/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">000F81</idno>
<idno type="wicri:Area/Main/Curation">000D97</idno>
<idno type="wicri:Area/Main/Exploration">001A31</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Positron emission tomography shows that impaired frontal lobe functioning in Parkinson’s disease is related to dopaminergic hypofunction in the caudate nucleus</title>
<author><name sortKey="Bruck, Anna" sort="Bruck, Anna" uniqKey="Bruck A" first="Anna" last="Brück">Anna Brück</name>
<affiliation wicri:level="4"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre, University of Turku, FIN-20520 Turku</wicri:regionArea>
<orgName type="university">Université de Turku</orgName>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Portin, Raija" sort="Portin, Raija" uniqKey="Portin R" first="Raija" last="Portin">Raija Portin</name>
<affiliation wicri:level="4"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Neurology, University of Turku, FIN-20520 Turku</wicri:regionArea>
<orgName type="university">Université de Turku</orgName>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lindell, Arja" sort="Lindell, Arja" uniqKey="Lindell A" first="Arja" last="Lindell">Arja Lindell</name>
<affiliation wicri:level="4"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Rehabilitation, University of Turku, FIN-20520 Turku</wicri:regionArea>
<orgName type="university">Université de Turku</orgName>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Laihinen, Arto" sort="Laihinen, Arto" uniqKey="Laihinen A" first="Arto" last="Laihinen">Arto Laihinen</name>
<affiliation wicri:level="4"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre, University of Turku, FIN-20520 Turku</wicri:regionArea>
<orgName type="university">Université de Turku</orgName>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bergman, Jorgen" sort="Bergman, Jorgen" uniqKey="Bergman J" first="Jörgen" last="Bergman">Jörgen Bergman</name>
<affiliation wicri:level="3"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Radiopharmaceutical Chemistry and Accelerator Laboratory, Åbo Akademi University, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haaparanta, Merja" sort="Haaparanta, Merja" uniqKey="Haaparanta M" first="Merja" last="Haaparanta">Merja Haaparanta</name>
<affiliation wicri:level="3"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Radiopharmaceutical Chemistry and Accelerator Laboratory, Åbo Akademi University, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Solin, Olof" sort="Solin, Olof" uniqKey="Solin O" first="Olof" last="Solin">Olof Solin</name>
<affiliation wicri:level="3"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Radiopharmaceutical Chemistry and Accelerator Laboratory, Åbo Akademi University, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name>
<affiliation wicri:level="1"><country wicri:rule="url">Finlande</country>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre, University of Turku, FIN-20520 Turku</wicri:regionArea>
<orgName type="university">Université de Turku</orgName>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Neuroscience Letters</title>
<title level="j" type="abbrev">NSL</title>
<idno type="ISSN">0304-3940</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="2001">2001</date>
<biblScope unit="volume">311</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="81">81</biblScope>
<biblScope unit="page" to="84">84</biblScope>
</imprint>
<idno type="ISSN">0304-3940</idno>
</series>
<idno type="istex">C422F2766080D75DEFC7CD0B588A2EEE9E9832F8</idno>
<idno type="DOI">10.1016/S0304-3940(01)02124-3</idno>
<idno type="PII">S0304-3940(01)02124-3</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0304-3940</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Caudate nucleus</term>
<term>Cognition</term>
<term>Frontal lobe functions</term>
<term>Parkinson's disease</term>
<term>Positron emission tomography</term>
<term>The Stroop test</term>
<term>[18F]fluorodopa</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We examined the relation between the dopaminergic function and the cognitive performance of patients with Parkinson's disease (PD). The subject sample consisted of ten patients in the early course of PD and with no previous antiparkinsonian medication. The dopaminergic function of the caudate nucleus and the putamen was studied with [18F]fluorodopa positron emission tomography, and the cognitive performance with a comprehensive battery of neuropsychological tests including tests sensitive to frontal lobe function. The decreased [18F]fluorodopa uptake in the right caudate nucleus was found to be related to slow processing time, measured as the difference between the incongruent and the congruent subtests of the Stroop Test (r=−0.85, P=0.002), a similar trend was seen in the left caudate (r=−0.60, P=0.07). Similar correlation was not detected in the putamen. The present findings provide evidence that the decreased dopaminergic function in the right caudate nucleus is related to the impaired performance in tests sensitive to frontal lobe function in patients at an early stage of PD and with no antiparkinsonian medication.</div>
</front>
</TEI>
<affiliations><list><country><li>Finlande</li>
</country>
<region><li>Finlande occidentale</li>
</region>
<settlement><li>Turku</li>
</settlement>
<orgName><li>Université de Turku</li>
</orgName>
</list>
<tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Bruck, Anna" sort="Bruck, Anna" uniqKey="Bruck A" first="Anna" last="Brück">Anna Brück</name>
</region>
<name sortKey="Bergman, Jorgen" sort="Bergman, Jorgen" uniqKey="Bergman J" first="Jörgen" last="Bergman">Jörgen Bergman</name>
<name sortKey="Haaparanta, Merja" sort="Haaparanta, Merja" uniqKey="Haaparanta M" first="Merja" last="Haaparanta">Merja Haaparanta</name>
<name sortKey="Laihinen, Arto" sort="Laihinen, Arto" uniqKey="Laihinen A" first="Arto" last="Laihinen">Arto Laihinen</name>
<name sortKey="Lindell, Arja" sort="Lindell, Arja" uniqKey="Lindell A" first="Arja" last="Lindell">Arja Lindell</name>
<name sortKey="Portin, Raija" sort="Portin, Raija" uniqKey="Portin R" first="Raija" last="Portin">Raija Portin</name>
<name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name>
<name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name>
<name sortKey="Solin, Olof" sort="Solin, Olof" uniqKey="Solin O" first="Olof" last="Solin">Olof Solin</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A31 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A31 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:C422F2766080D75DEFC7CD0B588A2EEE9E9832F8 |texte= Positron emission tomography shows that impaired frontal lobe functioning in Parkinson’s disease is related to dopaminergic hypofunction in the caudate nucleus }}
This area was generated with Dilib version V0.6.23. |